Inhibitory effect of tannic acid sulfate and related sulfates on infectivity, cytopathic effect, and giant cell formation of human immunodeficiency virus.

Abstract

The acquired immune deficiency syndrome (AIDS) is thought to result from infection of T cells by a pathogenic human retrovirus, human immunodeficiency virus [HIV (HTLV-III/LAV)]. In this report, we synthesized sulfated plant polyphenols such as tannic acid sulfate, rutin sulfate, ellagic acid sulfate, (-)-epicatechin sulfate, and (-)-epigallocatechin 3-gallate sulfate, and examined the in vitro inhibitory effect on HIV infection using human T-cell lymphotropic virus type-I-carrying MT-4 cells, which are extremely susceptible to HIV infection. Of the compounds tested, tannic acid sulfate was the most effective and had low cytotoxicity. Tannic acid sulfate completely inhibited the cytopathic effect of HIV and the HIV-specific antigen expression in MT-4 cells at the concentration of 6 micrograms/ml. In addition, this sulfate inhibited giant cell formation in coculture at the concentration of 5 micrograms/ml.

• Authors: T Mizuno, K Uchino, T Toukairin, A Tanabe, H Nakashima, N Yamamoto, H Ogawara
• Journal: Planta medica (Planta Med) Vol. 58 Issue 6 Pg. 535-9 (Dec 1992) ISSN: 0032-0943 [Print] Germany
• PMID: 1484893 (Publication Type: Journal Article)

Chemical References

• Flavonoids
• HIV Antigens
• Hydrolyzable Tannins
• Phenols
• Polymers
• Polyphenols
• Sulfates

Topics

• Cell Line
• Cytopathogenic Effect, Viral (drug effects)
• Flavonoids
• Giant Cells (drug effects)
• HIV (drug effects, pathogenicity)
• HIV Antigens (biosynthesis)
• Humans
• Hydrolyzable Tannins (chemistry, pharmacology)
• Molecular Structure
• Phenols (pharmacology)
• Polymers (pharmacology)
• Polyphenols
• Sulfates (pharmacology)