[Efficacy of alcoholates and clay in percutaneous contamination of rats with highly toxic organophosphorus compounds].

Abstract

Efficacy of decontamination by alcoholate and clay has been examined in animals percutaneously poisoned by nerve war gases (VX, soman) and organophosphorous insecticides (parathion, dichlorvos, terbufos) at exposure of 2, 5 and 60 minutes. High efficacy was achieved after two minutes using alcoholates which, except for VX, was lower for 50% after 5 minutes. The similar results were also achieved with clay in nerve war gas poisoning, however, the efficacy of this material was somewhat lower. By delayed decontamination (after 60 minutes) in animals poisoned by parathion and terbufos somewhat lower but still satisfying efficacy was achieved (ZI = 3.3, that is, 11.5). The results obtained have shown that efficacy of decontamination, except for the used materials, depends also on duration of the procedure.

• Authors: D Knezević, V Tadić
• Journal: Vojnosanitetski pregled (Vojnosanit Pregl) 1992 Jul-Aug Vol. 49 Issue 4 Pg. 343-7 ISSN: 0042-8450 [Print] Serbia
• Vernacular Title: Efikasnost alkoholata i gline kod perkutane kontaminacije pacova visoko toksicnim organofosfornim jedinjenjima.
• PMID: 1481449 (Publication Type: Journal Article)

Chemical References

• Acetals
• Aluminum Silicates
• Sulfones
• Dimethylformamide
• Clay

Topics

• Acetals (therapeutic use)
• Aluminum Silicates (therapeutic use)
• Animals
• Clay
• Dimethylformamide (therapeutic use)
• Female
• Organophosphate Poisoning
• Poisoning (therapy)
• Rats
• Rats, Wistar
• Sulfones (therapeutic use)