[Efficacy of pretreatment with adrenergic beta-receptor blockers in the prevention of cardiotoxic effects of isoprenaline in rats].

Abstract

Protective effects of beta-blockers, propranolol and atenolol, have been investigated in rats treated with cardiotoxic dose of isoprenaline. In saline-pretreated animals isoprenaline produced all morphological, biochemical and electrophysiological signs of myocardial necrosis: massive coagulation necrosis of cardiomyocytes, 2.6 to 3.5-fold increase of creatine-kinase, lactate-dehydrogenase and alpha-hydroxybutyrate-dehydrogenase plasma activity and Q-wave and ST-segment elevation in ECG. Both beta-blockers protected only partly the rats heart muscle from the cardionecrogenic action of isoprenaline while propranolol has been slightly more efficient, probably due to its combined beta-blocking and antiperoxidative activity.

• Authors: P Ljubuncić, M P Stojiljković, M Winterhalter-Jadrić, Z Vidović, F Mujić
• Journal: Vojnosanitetski pregled (Vojnosanit Pregl) 1992 Jul-Aug Vol. 49 Issue 4 Pg. 297-304 ISSN: 0042-8450 [Print] Serbia
• Vernacular Title: Efikasnost predtretmana blokatorima beta-adrenergickih receptora u suzbijanju kardiotoksicnih efekata izoprenalina u pacova.
• PMID: 1481441 (Publication Type: English Abstract, Journal Article)

Chemical References

• Atenolol
• Propranolol
• Isoproterenol

Topics

• Animals
• Atenolol (pharmacology)
• Electrocardiography (drug effects)
• Heart (drug effects)
• Isoproterenol (toxicity)
• Male
• Propranolol (pharmacology)
• Rats
• Rats, Wistar