[Zinc content in pancreatic islets in experimental diabetes induced by chelating agents].

Abstract

The zinc content in microresected islets of rabbits, mice, rats, and guinea pigs was determined by atom-absorption spectrophotometry. The content was found to be highest in rabbits, and diabetes was induced in them by chelating agents easily. Injection of dithizone or 8-(p-toluenesulfonylamine) quinoline failed to induce diabetes mellitus in mice, rats, and guinea pigs. It is concluded that diabetogenic chelating agents are capable of producing irreversible diabetogenic affection in those beta-cells which contain a critical concentration of reactant zinc.

• Authors: Z E Bavel'skiĭ, T V Zaviazkina, Iu S Moiseev, V I Medvedev
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1992 May-Jun Issue 3 Pg. 29-32 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Soderzhanie tsinka v pankreaticheskikh ostrovkakh i éksperimental'nyĭ diabet, vyzyvaemyĭ khelatoobrazovateliami.
• PMID: 1480418 (Publication Type: English Abstract, Journal Article)

Chemical References

• Chelating Agents
• Zinc

Topics

• Animals
• Chelating Agents
• Diabetes Mellitus, Experimental (chemically induced, metabolism)
• Female
• Guinea Pigs
• Islets of Langerhans (metabolism)
• Male
• Mice
• Rabbits
• Rats
• Rats, Wistar
• Zinc (metabolism)