[Comparative evaluation of the wound-healing effect of benzofuracaine, etaden, and xanthinol nicotinate in an experiment].

Abstract

The effect of benzofuracaine, etaden, and xanthinol nicotinate on the healing of skin wounds was studied in rat experiments. On days 1-14 of postmechanical injury, intramuscular benzofuracaine (15, 30, 60, and 120 mg/kg), etaden (20 mg/kg), and xanthinol nicotinate (each drug alone) reparative processes in the skin wounds developed more rapidly and processes of microcirculation in the region of the injury were normalized. The wound-healing effect of benzofurocaine in an ortimal dose of 60 mg/kg was more marked than that op etaden and xanthinol nicotinate. With benzofuracaine and etaden, the skin wounds healed completely by the 14th day of the experiment in 57% and 28.6% of animals, respectively. Such cases were not encountered among animals treated with xanthinol nicotinate and in the controls (untreated animals).

• Authors: G I Stepaniuk, V V Ornostaĭ, V G Kozlov
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1992 May-Jun Issue 3 Pg. 16-8 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Sravnitel'naia otsenka ranozazhivliaiushchego deĭstviia benzofurokaina, étadena i ksantinola nikotinata v éksperimente.
• PMID: 1480413 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anesthetics, Local
• Anti-Inflammatory Agents, Non-Steroidal
• Benzofurans
• etaden
• Xanthinol Niacinate
• benzofurocaine
• Adenine

Topics

• Adenine (analogs & derivatives, pharmacology)
• Anesthetics, Local (pharmacology)
• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Benzofurans
• Female
• Male
• Rats
• Wound Healing (drug effects)
• Xanthinol Niacinate (pharmacology)