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[Eosinophilic leukemia with cyclic eosinophilic leukocytosis].

Abstract
A 36-year-old male was admitted to the Ehime University Hospital with anemia, eosinophilia and hepatosplenomegaly. Peripheral blood examination demonstrated severe anemia (Hb 7.1g/dl), thrombocytopenia (Plt 6.8 x 10(4)/microliters) and increase of peripheral leukocyte counts (53,000/microliters) with 32.0% of eosinophils which had lobulated nuclei, abnormal distribution of eosinophilic granules and a few vacuoles. The level of serum IgE was low (< 5IU/ml), while that of serum vitamin B12 was elevated. A diagnosis of eosinophilic leukemia was made. He was noted to have spontaneous fluctuations in his eosinophil and total leukocyte counts. To analyze the mechanism of cyclic eosinophilic leukocytosis, we examined eosinophil colony stimulating activity of the serum and plasma of the patient. These examination showed that eosinophil colony-stimulating activity was not found in his serum and plasma, and cyclic eosinophilic leukocytosis was due to the hemopoietic stem cell disorder.
AuthorsE Sada, K Yanagisawa, H Hasegawa, S Fujita, Y Kobayashi, H Kono, T Kondo
Journal[Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 33 Issue 12 Pg. 1884-9 (Dec 1992) ISSN: 0485-1439 [Print] Japan
PMID1479703 (Publication Type: Case Reports, English Abstract, Journal Article)
Topics
  • Adult
  • Eosinophils
  • Hematopoietic Stem Cells (physiology)
  • Humans
  • Leukemia, Eosinophilic, Acute (blood, pathology)
  • Leukocyte Count
  • Leukocytosis (pathology)
  • Male
  • Periodicity

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