Studies on the synthesis of sesquiterpene lactones, 14. Syntheses of (-)-arbusclin D and (+)-4-EPI-arbusclin D: the stereochemical assignment of arbusclin D.

Abstract

Efficient syntheses of (-)-arbusclin D and (+)-4-epi-arbusclin D are reported. By these syntheses the C-4 stereochemistry of arbusclin D and the absolute configuration of (-)-arbusclin D have been determined to be a s shown in structure 1. The biological activities, such as cytotoxic activity toward P-388 lymphocytic leukemia, plant growth regulating activity, and antimicrobial activity of compounds 1, 3, 7, 9, 12, and 14 were also studied.

• Authors: M Ando, K Isogai, H Azami, N Hirata, H Yamazaki, Y Yanagi
• Journal: Journal of natural products (J Nat Prod) Vol. 55 Issue 11 Pg. 1620-5 (Nov 1992) ISSN: 0163-3864 [Print] United States
• PMID: 1479379 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Lactones
• Plant Growth Regulators
• Sesquiterpenes
• Sesquiterpenes, Eudesmane
• arbusclin D

Topics

• Animals
• Antineoplastic Agents, Phytogenic (chemical synthesis, chemistry)
• Lactones (chemical synthesis, pharmacology)
• Leukemia P388 (drug therapy)
• Mice
• Plant Growth Regulators (pharmacology)
• Sesquiterpenes (chemical synthesis, pharmacology)
• Sesquiterpenes, Eudesmane