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Effects of phenylalaninol on centrally induced gastric acid secretion.

Abstract
The effects of phenylalaninol (D-isomer) on gastric acid secretion and gastric ulcer were studied in rats. The compound reduced the gastric acid secretion stimulated by intracisternal thyrotropin releasing hormone and intravenous 2-deoxy-D-glucose, but not that stimulated by subcutaneous carbachol or histamine. Phenylalaninol prevented stress- and indomethacin-induced gastric ulcers. We conclude that phenylalaninol inhibits ulcer formation mainly by central inhibition of gastric acid secretion.
AuthorsH Hashizume, T Miyamae, T Morikawa, M Hagiwara
JournalChemical & pharmaceutical bulletin (Chem Pharm Bull (Tokyo)) Vol. 40 Issue 11 Pg. 3113-4 (Nov 1992) ISSN: 0009-2363 [Print] Japan
PMID1477931 (Publication Type: Journal Article)
Chemical References
  • phenylalaninol
  • Phenylalanine
  • Thyrotropin-Releasing Hormone
  • Histamine
  • Carbachol
  • Deoxyglucose
Topics
  • Animals
  • Carbachol (pharmacology)
  • Deoxyglucose (pharmacology)
  • Gastric Acid (metabolism)
  • Histamine (pharmacology)
  • Male
  • Phenylalanine (analogs & derivatives, pharmacology, therapeutic use)
  • Rats
  • Rats, Wistar
  • Stomach Ulcer (prevention & control)
  • Thyrotropin-Releasing Hormone (pharmacology)

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