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Effect of propranolol in head tremor: quantitative study following single-dose and sustained drug administration.

Abstract
The effect of the beta-adrenoceptor antagonist propranolol has been investigated in nine patients suffering from isolated (six patients) or prominent (three patients) essential tremor of the head. In a double-blind, placebo-controlled study the tremorolytic efficacy of propranolol has been assessed by a quantitative accelerometric method after a single oral dose (120 mg) and following 2 weeks of sustained treatment with two different dosage regimens of the drug (120 and 240 mg daily). As compared with placebo, a significant reduction in tremor magnitude was found following a single oral dose but not on sustained administration of the beta-blocker at either dosage. The results suggest that the efficacy of sustained propranolol on isolated or prominent essential head tremor is less predictable and satisfactory than expected on the basis of the single-dose response, as compared with hand tremor.
AuthorsS Calzetti, E Sasso, A Negrotti, M Baratti, R Fava
JournalClinical neuropharmacology (Clin Neuropharmacol) Vol. 15 Issue 6 Pg. 470-6 (Dec 1992) ISSN: 0362-5664 [Print] United States
PMID1477848 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Delayed-Action Preparations
  • Propranolol
Topics
  • Adult
  • Aged
  • Delayed-Action Preparations
  • Double-Blind Method
  • Female
  • Head
  • Humans
  • Male
  • Middle Aged
  • Propranolol (adverse effects, pharmacokinetics, therapeutic use)
  • Pulse (drug effects)
  • Tremor (drug therapy, physiopathology)

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