[Organic calcium antagonists verapamil and ryodipine prevent an increase of free calcium in synaptosomes of the rat brain during corazol kindling].
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| Abstract |
In experiments on Wistar male rats it was shown that i.p. administration of verapamil or ryodipine (1,4-dihydropyridine) 15 min before each daily injection of pentylenetetrazol (PTZ) in a subconvulsive dose 30 mg/kg during 28 days significantly delayed the development of PTZ-induced kindling and attenuated kindled seizure reactions during 21-23 days as compared with control. One week after kindling an increase in free Ca2+ concentration in control rat brain synaptosomes by 60% was revealed; the treatment by verapamil and ryodipine prevented this increase. Nevertheless, Ca2+ antagonists studied at least under our experimental conditions inspite of a significant decrease in free Ca2+ concentration in synaptosomes would not completely prevent the development of kindling. Thus, an alteration in calcium homeostasis will not be the only mechanism of plasticity and long-term changes of neurons during kindling.
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| Authors | M N Karpova, N M Antonikov, O Iu Pankov, R N Glebov |
| Journal | Biulleten' eksperimental'noi biologii i meditsiny (Biull Eksp Biol Med) Vol. 114 Issue 9 Pg. 252-4 (Sep 1992) ISSN: 0365-9615 [Print] Russia (Federation) |
| Vernacular Title | Organicheskie antagonisty kal'tsiia verapamil i riodipin predotvrashchaiut uvelichenie svobodnogo kal'tsiia v sinaptosomakh mozga krys v techenie korazolovogo kindlinga. |
| PMID | 1477346 (Publication Type: Comparative Study, English Abstract, Journal Article) |
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