Abstract | BACKGROUND: METHODS AND RESULTS: In this multicenter, double-blind, randomized, placebo-controlled study, we examined whether treatment with ezetimibe, an inhibitor of cholesterol absorption, reduces plant sterol levels in patients with sitosterolemia. After a 3-week placebo run-in, 37 patients were randomized to receive placebo (n=7) or ezetimibe 10 mg/d ( n=30) for 8 weeks. Sitosterol concentrations decreased by 21% (P<0.001) in patients treated with ezetimibe compared with a nonsignificant 4% rise in those on placebo (between-group P<0.001). The reduction in sitosterol from baseline was progressive, with further decline observed at each subsequent biweekly visit. Campesterol also progressively declined, with a mean decrease after 8 weeks of 24% with ezetimibe and a mean increase of 3% with placebo treatment (between-group P<0.001). Reductions in plant sterol concentrations were similar irrespective of whether patients were undergoing concomitant treatment with resin or statin. Reductions in total sterols and apolipoprotein B were also observed. Ezetimibe was well tolerated, with no serious treatment-related adverse events or discontinuations due to adverse events being reported. CONCLUSIONS:
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Authors | G Salen, K von Bergmann, D Lütjohann, P Kwiterovich, J Kane, S B Patel, T Musliner, P Stein, B Musser, Multicenter Sitosterolemia Study Group |
Journal | Circulation
(Circulation)
Vol. 109
Issue 8
Pg. 966-71
(Mar 02 2004)
ISSN: 1524-4539 [Electronic] United States |
PMID | 14769702
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- ABCG5 protein, human
- ABCG8 protein, human
- ATP Binding Cassette Transporter, Subfamily G, Member 5
- ATP Binding Cassette Transporter, Subfamily G, Member 8
- ATP-Binding Cassette Transporters
- Anticholesteremic Agents
- Apolipoproteins B
- Azetidines
- Cholesterol, Dietary
- Lipoproteins
- Phytosterols
- Sitosterols
- campesterol
- Cholesterol
- Ezetimibe
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Topics |
- ATP Binding Cassette Transporter, Subfamily G, Member 5
- ATP Binding Cassette Transporter, Subfamily G, Member 8
- ATP-Binding Cassette Transporters
(genetics)
- Adolescent
- Adult
- Aged
- Anticholesteremic Agents
(therapeutic use)
- Apolipoproteins B
(blood)
- Arteriosclerosis
(genetics, prevention & control)
- Azetidines
(therapeutic use)
- Child
- Cholesterol
(analogs & derivatives, blood)
- Cholesterol, Dietary
(pharmacokinetics)
- Double-Blind Method
- Ezetimibe
- Female
- Genes, Recessive
- Humans
- Intestinal Absorption
(drug effects)
- Lipid Metabolism, Inborn Errors
(blood, complications, drug therapy)
- Lipoproteins
(deficiency, genetics)
- Male
- Middle Aged
- Phytosterols
(pharmacokinetics)
- Sitosterols
(blood, pharmacokinetics)
- Treatment Outcome
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