Long-term retention of neurotoxic beta-carbolines in brain neuromelanin.

Abstract

beta-Carbolines show structural resemblance to the neurotoxic N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine and are metabolized to mitochondrial toxicants. Humans are continuously exposed to low levels of beta-carbolines through cooked food, coffee, alcoholic beverages and tobacco smoke. beta-Carbolines have previously been detected in higher levels in the pigmented substantia nigra than in the cortex of humans. The distribution of 3H-labelled harman and norharman in the brain of pigmented and albino mice and in frogs (a species having neuromelanin) was studied by tape-section and light-microscopic autoradiography. Furthermore, the binding of these beta-carbolines to dopamine-melanin and melanin granules from Sepia officinalis was examined. The results revealed a high affinity binding to melanin and a long-term retention (up to 30 days) in pigmented tissues, including neuromelanin-containing neurons of frogs after a single injection. The role of long-term exposure to food-related beta-carbolines and a retention of these compounds in pigment-containing neurons in the induction of idiopathic Parkinson's disease should be further considered.

• Authors: A Ostergren, A Annas, K Skog, N G Lindquist, E B Brittebo
• Journal: Journal of neural transmission (Vienna, Austria : 1996) (J Neural Transm (Vienna)) Vol. 111 Issue 2 Pg. 141-57 (Feb 2004) ISSN: 0300-9564 [Print] Austria
• PMID: 14767717 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Carbolines
• Melanins
• neuromelanin

Topics

• Animals
• Brain (cytology, metabolism)
• Carbolines (analysis, metabolism)
• Female
• Melanins (analysis, metabolism)
• Mice
• Mice, Inbred C57BL
• Protein Binding (physiology)
• Rana temporaria
• Time