HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Carbon coated zirconium beads in beta-glucan gel and bovine glutaraldehyde cross-linked collagen injections for intrinsic sphincter deficiency: continence and satisfaction after extended followup.

AbstractPURPOSE:
The durability of Durasphere (Carbon Medical Technologies, Saint Paul, Minnesota), used to treat stress urinary incontinence, has not been shown beyond 12 months of followup. Women treated with Durasphere and Contigen (Bard, Inc., Covington, Georgia) at 1 institution between 1996 and 2000 were compared to determine patient satisfaction and urinary continence after extended followup.
MATERIALS AND METHODS:
Between April 1996 and September 2000, 56 women were treated with Durasphere at this institution, of whom 43 were available for extended followup. Aged matched patients treated with Contigen were analyzed for comparison. Patient satisfaction and continence at last followup were subjectively assessed via telephone interview. Survival methods (Kaplan-Meier and Cox proportional hazards model) were used to analyze time to failure as a function of treatment group and other potential predictors.
RESULTS:
Treatment groups (Contigen and Durasphere) were similar with respect to all baseline factors. Treatment was initially effective in 63% of Durasphere and Contigen cases (p = 1.0). At 24 and 36 months Durasphere remained effective in 33% and 21% of patients compared with 19% and 9% for Contigen, respectively. At last followup only 9 patients (21%) treated with Durasphere and 2 (5%) treated with Contigen (median followup 51 and 62 months, respectively) claimed that treatment was still effective. After controlling for differences in followup time there was no significant difference in time to failure between the treatment groups (p = 0.25). A third of patients in each group believed that treatment was a success.
CONCLUSIONS:
Neither Contigen nor Durasphere provides durable improvement in continence. Despite this outcome a third of patients in the 2 groups were satisfied with the treatment outcome.
AuthorsK L Chrouser, F Fick, A Goel, N B Itano, S D Sweat, D J Lightner
JournalThe Journal of urology (J Urol) Vol. 171 Issue 3 Pg. 1152-5 (Mar 2004) ISSN: 0022-5347 [Print] United States
PMID14767290 (Publication Type: Comparative Study, Journal Article)
Chemical References
  • Biocompatible Materials
  • Gels
  • Glucans
  • durasphere
  • glutaraldehyde-cross-linked collagen
  • Collagen
  • Zirconium
Topics
  • Administration, Intravesical
  • Aged
  • Biocompatible Materials
  • Collagen (administration & dosage)
  • Follow-Up Studies
  • Gels
  • Glucans
  • Humans
  • Male
  • Patient Satisfaction
  • Time Factors
  • Urinary Incontinence, Stress (therapy)
  • Zirconium

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: