| Abstract | Patients with relapsed acute myeloid leukemia following autograft have a poor prognosis. The possibility of allograft is frequently time-limited, as the disease reappears before a stem cell donor can be found in the worldwide registries. Cord blood transplantation is a new therapeutic approach, since cord blood units are rapidly available. The authors show how a relapsed chemotherapy-refractory patient was successful transplanted with a mismatched cord blood unit after reduced-intensity conditioning. Twenty-three months after transplantation, the child is in continuous complete remission and has full donor chimerism and no signs of chronic graft-versus-host disease. |
| Authors | Massimo Berger, Elena Vassallo, Francesca Nesi, Claudio Venturi, Enrico Madon, Franca Fagioli
(Affiliation: Department of Paediatrics, Regina Margherita Children's Hospital, University of Turin, Italy.)
|
| Journal | Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology
(J Pediatr Hematol Oncol)
Vol. 26
Issue 2
Pg. 98-100
(Feb 2004)
ISSN: 1077-4114 United States |
| PMID | 14767195
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
|
| Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Child, Preschool
- Cord Blood Stem Cell Transplantation
- Graft vs Host Disease
(prevention & control)
- Graft vs Leukemia Effect
(immunology)
- Humans
- Leukemia, Myelomonocytic, Acute
(therapy)
- Male
- Neoplasm Recurrence, Local
(therapy)
- Remission Induction
- Transplantation Conditioning
- Treatment Outcome
|
