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[Correlation of the lipophilicity of the active agents with their topical anti-inflammatory activity].

Abstract
The present study concerns the relation between the therapeutic activity of some FANS in formulation for topical use and their lipophylic nature. The efficacy of topic formulations of three widely used FANS: cinnoxicam, piroxicam and diclofenac have been evaluated through the decrease of plantar edema induced by egg's white in the rat's hind paw. The volume increases after one hour were 55% in the group of rats treated with cinnoxicam, 64% in the animals treated with piroxicam and 79% in those treated with diclofenac, against 86% of control group. The partition coefficient (P) of the three active drugs have been detected. The P found for the three drugs 4.9, 3.3, 0.9 respectively demonstrate the direct correlation between the pharmacological activity of the topic formulation and its lipophylic nature.
AuthorsM Berti, R Cantoni, P Mosconi, P Pattini
JournalBollettino chimico farmaceutico (Boll Chim Farm) 1992 Jul-Aug Vol. 131 Issue 7 Pg. 270-3 ISSN: 0006-6648 [Print] Italy
Vernacular TitleCorrelazione tra lipofilia del principio attivo ed attività antiinfiammatoria per via topica.
PMID1476697 (Publication Type: Journal Article)
Chemical References
  • Anti-Inflammatory Agents
  • Lipids
Topics
  • Administration, Topical
  • Animals
  • Anti-Inflammatory Agents (chemistry, pharmacology)
  • Chemical Phenomena
  • Chemistry, Physical
  • Female
  • Lipids (chemistry)
  • Rats
  • Rats, Wistar

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