Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages.

Abstract

In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibitors of some macrophage functions involved in the inflammatory process. These five compounds significantly inhibited lipopolysaccharide (LPS)-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) in a concentration-dependent manner. In the tumour necrosis factor-alpha (TNF-alpha) assay, only centaureidin and hydroxyachillin significantly inhibited the accumulation of TNF-alpha. These results indicate that these compounds may contribute to the anti-inflammatory properties of T. microphyllum.

• Authors: María José Abad, Paulina Bermejo, María Alvarez, José Antonio Guerra, Ana María Silván, Angel Maria Villar
• Journal: Planta medica (Planta Med) Vol. 70 Issue 1 Pg. 34-8 (Jan 2004) ISSN: 0032-0943 [Print] Germany
• PMID: 14765290 (Publication Type: Journal Article)

Chemical References

• Flavonoids
• Lactones
• Lipopolysaccharides
• Sesquiterpenes
• Tumor Necrosis Factor-alpha
• Nitric Oxide
• Dinoprostone

Topics

• Animals
• Dinoprostone (metabolism)
• Dose-Response Relationship, Drug
• Flavonoids (administration & dosage, pharmacology, therapeutic use)
• Lactones (administration & dosage, pharmacology, therapeutic use)
• Lipopolysaccharides
• Macrophages, Peritoneal (drug effects)
• Male
• Mice
• Nitric Oxide (metabolism)
• Phytotherapy
• Plant Components, Aerial
• Sesquiterpenes (administration & dosage, pharmacology, therapeutic use)
• Tanacetum
• Tumor Necrosis Factor-alpha (drug effects, metabolism)