Cancer chemopreventive activity of rotenoids from Derris trifoliata.

Abstract

A study of the chemical constituents of the stems of Derris trifoliata Lour. (Leguminosae) led to the isolation and identification of one new rotenoid, 6aalpha,12aalpha-12a-hydroxyelliptone ( 3), together with five other known rotenoids. In a search for novel cancer chemopreventive agents (anti-tumor promoters), we carried out a primary screening of five of the rotenoids isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12- O-tetradecanoylphorbol 13-acetate (TPA) in Raji cells. The inhibitory activity of 3 was found to be equivalent to that of beta-carotene without any cytotoxicity. Deguelin ( 4) and alpha-toxicarol ( 5) exhibited a marked inhibitory effect on mouse skin tumor promotion in an in vivo two-stage carcinogenesis test. This investigation indicated that rotenoids might be valuable anti-tumor promoters.

• Authors: Chihiro Ito, Masataka Itoigawa, Naoki Kojima, Hugh T-W Tan, Junko Takayasu, Harukuni Tokuda, Hoyoku Nishino, Hiroshi Furukawa
• Journal: Planta medica (Planta Med) Vol. 70 Issue 1 Pg. 8-11 (Jan 2004) ISSN: 0032-0943 [Print] Germany
• PMID: 14765285 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anticarcinogenic Agents
• Antigens, Viral
• Epstein-Barr virus early antigen
• Plant Extracts
• Rotenone

Topics

• Animals
• Anticarcinogenic Agents (administration & dosage, pharmacology, therapeutic use)
• Antigens, Viral (drug effects)
• Cell Line, Tumor
• Cell Survival (drug effects)
• Derris
• Drug Screening Assays, Antitumor
• Female
• Mice
• Mice, Inbred ICR
• Phytotherapy
• Plant Extracts (administration & dosage, pharmacology, therapeutic use)
• Plant Stems
• Rotenone (administration & dosage, pharmacology, therapeutic use)
• Skin Neoplasms (prevention & control)