Abstract | OBJECTIVE: METHODS: RESULTS: Two hospital deaths occurred: one patient died on the fifth postoperative day of graft failure, and the second died on the 17th postoperative day after an acute neurologic event. Two patients died later, one 23 months after transplantation of acute rejection and the other after 90 months of chronic rejection and endocarditis. One patient underwent successful reintervention 2 years after heart transplantation for pulmonary vein obstruction. The 10 surviving patients are in New York Heart Association class I, with a mean follow-up of 64.5 +/- 42 months. One of them was delivered of a healthy baby 5 years after transplantation. Patients with protein-losing enteropathy reached a normal protein level within a mean of 10 months (range, 6-18 months) after transplantation. Four patients required a temporary administration (3-6 months) of oral steroid therapy for recurrent rejection episodes. Currently, 7 patients are taking cyclosporine, and 3 are taking cyclosporine and azathioprine. The actuarial survival at 1, 5, and 10 years was 86% +/- 9%, 77% +/- 12%, and 62% +/- 17%, respectively. CONCLUSION:
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Authors | Amando Gamba, Maurizio Merlo, Roberto Fiocchi, Amedeo Terzi, Carmelo Mammana, Roberta Sebastiani, Paolo Ferrazzi |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 127
Issue 2
Pg. 555-62
(Feb 2004)
ISSN: 0022-5223 [Print] United States |
PMID | 14762368
(Publication Type: Comparative Study, Evaluation Study, Journal Article)
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Chemical References |
- Biomarkers
- Blood Proteins
- Immunosuppressive Agents
- Cyclosporine
- Creatinine
- Mycophenolic Acid
- Azathioprine
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Topics |
- Adolescent
- Adult
- Azathioprine
(administration & dosage)
- Biomarkers
(blood)
- Blood Proteins
(metabolism)
- Cardiac Output, Low
(mortality, surgery)
- Child
- Child, Preschool
- Creatinine
(blood)
- Cyclosporine
(administration & dosage)
- Drug Therapy, Combination
- Female
- Follow-Up Studies
- Fontan Procedure
- Heart Defects, Congenital
(mortality, surgery)
- Heart Transplantation
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Italy
- Length of Stay
- Male
- Mycophenolic Acid
(administration & dosage, analogs & derivatives)
- Postoperative Complications
(etiology, mortality, therapy)
- Reoperation
- Retrospective Studies
- Severity of Illness Index
- Survival Analysis
- Time Factors
- Treatment Outcome
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