Abstract | BACKGROUND: METHODS: In a prospective study of 300 patients with acute MI, we evaluated the predictive value of FXIIa in blood samples drawn 4 to 6 days after admission. Cardiac death, re-MI, and troponin-T-positive unstable angina pectoris were registered during a median follow-up period of 1.5 years. RESULTS: In the upper quartile of FXIIa (Q4) (> or =2.23 ng/mL) 32.0% of patients had an ACS as compared with 16.9% of patients with FXIIa in the three lower quartiles (Q1-3, P =.008). Relative risk of recurrent ACS for patients with FXIIa in the Q4 as compared with Q1-3 was 1.89 (95% CI, 1.22 to 2.93). A secondary ACS occurred earlier in patients with FXIIa in the Q4 as compared with those with FXIIa in the Q1-3 (P =.0039). Conventional risk factors as potential confounders were not associated with time to event. FXIIa did not correlate with FM or microCRP, and the FM and microCRP levels were of a similar magnitude in the Q4 as compared with the Q1 and the Q1-3 of FXIIa. CONCLUSIONS: FXIIa predicts recurrent coronary events after MI. The prognostic ability of FXIIa was not reflected by markers of hypercoagulability or inflammation.
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Authors | Heidi Grundt, Dennis Winston T Nilsen, Øyvind Hetland, Edward Valente, Hans Eirik Fagertun |
Journal | American heart journal
(Am Heart J)
Vol. 147
Issue 2
Pg. 260-6
(Feb 2004)
ISSN: 1097-6744 [Electronic] United States |
PMID | 14760323
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Fibrin Fibrinogen Degradation Products
- Troponin T
- fibrinmonomer
- C-Reactive Protein
- Factor XIIa
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Topics |
- Angina, Unstable
(blood, epidemiology)
- Biomarkers
(blood)
- C-Reactive Protein
(analysis)
- Factor XIIa
(analysis)
- Female
- Fibrin Fibrinogen Degradation Products
(analysis)
- Humans
- Male
- Myocardial Infarction
(blood)
- Prognosis
- Proportional Hazards Models
- Prospective Studies
- Recurrence
- Risk Factors
- Troponin T
(blood)
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