Abstract | BACKGROUND: PATIENTS AND METHODS: One hundred patients with Hodgkin's disease (97 with stage I-II disease at presentation) who relapsed after radiation therapy alone were salvaged with either MOPP or ABVD. Freedom from second relapse (FFSR) and overall survival (OS) were determined, and prognostic factors for salvage outcome were evaluated. RESULTS: The median follow-up time since salvage therapy was 12 years. The 10-year FFSR and OS rates were 70% and 89%, respectively. Forty-one patients were salvaged with MOPP and 59 received ABVD. The type of salvage chemotherapy did not significantly influence FFSR or OS. Age >50 years at initial diagnosis was the only significant predictor for an inferior FFSR and OS on both univariate and multivariate analyses. CONCLUSIONS: The two salvage regimens of MOPP and ABVD had similar efficacy in this group of patients with predominantly early-stage disease at initial radiation therapy. The inferior salvage outcome in patients aged >50 years is a contributing factor to the overall poor prognosis of patients presenting with Hodgkin's disease at an older age.
|
Authors | A K Ng, S Li, D Neuberg, B Silver, M A Stevenson, D C Fisher, P M Mauch |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 15
Issue 2
Pg. 270-5
(Feb 2004)
ISSN: 0923-7534 [Print] England |
PMID | 14760121
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
|
Chemical References |
- Bleomycin
- Procarbazine
- Mechlorethamine
- Vincristine
- Vinblastine
- Dacarbazine
- Doxorubicin
- Prednisone
|
Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage, therapeutic use)
- Bleomycin
(administration & dosage)
- Dacarbazine
(administration & dosage)
- Disease-Free Survival
- Doxorubicin
(administration & dosage)
- Female
- Hodgkin Disease
(drug therapy, pathology, radiotherapy)
- Humans
- Male
- Mechlorethamine
(administration & dosage)
- Middle Aged
- Neoplasm Staging
- Prednisone
(administration & dosage)
- Procarbazine
(administration & dosage)
- Prognosis
- Recurrence
- Salvage Therapy
- Vinblastine
(administration & dosage)
- Vincristine
(administration & dosage)
|