Abstract | BACKGROUND: OBJECTIVE: METHODS: RESULTS: All had some degree of improvement of their dermatologic disease following 6-8 weeks of treatment with topical tacrolimus 0.1% ointment. Two had dramatic responses (>90% improvement), one had moderate (40-90%) improvement and three had minimal (20-40%) improvement. CONCLUSIONS: The dermatologic manifestations of dermatomyositis can be very difficult to treat. Multiple systemic and topical therapies have been studied. Combinations of treatments are often used, sometimes still not successfully. The results of this brief observational study using topical tacrolimus ointment for the treatment of refractory cutaneous lesions of dermatomyositis are encouraging. Topical tacrolimus was a useful adjunct in the treatment of the dermatologic component of dermatomyositis in adults and children in this pilot study.
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Authors | C B Hollar, J L Jorizzo |
Journal | The Journal of dermatological treatment
(J Dermatolog Treat)
Vol. 15
Issue 1
Pg. 35-9
(Jan 2004)
ISSN: 0954-6634 [Print] England |
PMID | 14754648
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Immunosuppressive Agents
- Ointments
- Tacrolimus
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Topics |
- Administration, Cutaneous
- Aged
- Child, Preschool
- Dermatomyositis
(drug therapy)
- Female
- Humans
- Immunosuppressive Agents
(administration & dosage)
- Male
- Middle Aged
- Ointments
- Pilot Projects
- Tacrolimus
(administration & dosage)
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