Neuroprotective effect from ischemia and direct free radical scavenging activity of Choto-san (kampo medicine).

Abstract

Choto-san is a kampo medicine that is widely used in patients with cerebral infarction, but the details of its mechanism of action remain unclear. We examined the neuroprotective effects of Choto-san using an experimental cerebral ischemia model (i.e., a rat cardiac arrest model). We also investigated the ability of Choto-san to eliminate or inhibit the activity of free radicals. It was found that Choto-san significantly prevents delayed neuronal cell death after ischemic reperfusion. Electron spin resonance demonstrated that the formation of hydroxyl- and superoxide-DMPO spin adducts were inhibited by Choto-san. The results of this study indicated that Choto-san prevents delayed neuronal cell death in the hippocampal CA1 region after ischemia. Direct free radical scavenging activity is among the pharmacological effects of Choto-san.

• Authors: K Dohi, K Satoh, Y Ikeda, H Ohtaki, S Shioda, T Aruga
• Journal: Acta neurochirurgica. Supplement (Acta Neurochir Suppl) Vol. 86 Pg. 123-7 ( 2003) ISSN: 0065-1419 [Print] Austria
• PMID: 14753419 (Publication Type: Journal Article)

Chemical References

• Drugs, Chinese Herbal
• Free Radical Scavengers
• Neuroprotective Agents
• choto-san
• Superoxides
• Hydroxyl Radical

Topics

• Animals
• Apoptosis (drug effects)
• Brain (pathology, physiopathology)
• Brain Ischemia (pathology, physiopathology)
• Drugs, Chinese Herbal (pharmacology)
• Electron Spin Resonance Spectroscopy
• Free Radical Scavengers (pharmacology)
• Hydroxyl Radical (antagonists & inhibitors)
• In Situ Nick-End Labeling
• Male
• Medicine, Kampo
• Neuroprotective Agents (pharmacology)
• Rats
• Rats, Sprague-Dawley
• Superoxides (antagonists & inhibitors)