Abstract | BACKGROUND: METHODS: Twenty-five patients with Barrett's esophagus were randomized to receive 30 (low-dose) or 60 (high-dose) mg/kg oral ALA at 4 or 6 h or 30 mg/kg in two fractions 4 and 6 h before PDT. PDT was standardized using red (635 nm) light. Biopsy specimens were taken for protoporphyrin IX ( PpIX) quantification. Endoscopy was repeated 4 weeks later. RESULTS: All patients showed a macroscopic response, with squamous re-epithelialization. This response was greatest in the 30 mg/kg and fractionated ALA groups. There was no significant difference in response between dosing 4 or 6 h prior to PDT. Tissue levels of PpIX were similar for all dosage groups and were not predictive of clinical response. Side effects were more common with the higher dose of ALA. CONCLUSION:
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Authors | C J Kelty, R Ackroyd, N J Brown, S B Brown, M W R Reed |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 18
Issue 3
Pg. 452-8
(Mar 2004)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 14752635
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Protoporphyrins
- Aminolevulinic Acid
- protoporphyrin IX
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Topics |
- Administration, Oral
- Adult
- Aged
- Aged, 80 and over
- Aminolevulinic Acid
(administration & dosage, therapeutic use)
- Barrett Esophagus
(drug therapy)
- Cohort Studies
- Dose-Response Relationship, Drug
- Drug Administration Schedule
- Female
- Humans
- Lasers
- Male
- Middle Aged
- Photochemotherapy
- Protoporphyrins
(analysis)
- Treatment Outcome
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