Delta sleep-inducing peptide and its tetrapeptide analogue alleviate severity of metaphit seizures.
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| Abstract |
The effects of delta sleep-inducing peptide (DSIP) and its tetrapeptide analogue, DSIP(1-4), on metaphit-induced audiogenic seizures were studied. Five groups of adult male Wistar rats were intraperitoneally treated with (1) saline, (2) metaphit, (3) DSIP, (4) metaphit+DSIP and (5) metaphit+DSIP(1-4). To examine blocking effects of DSIP and its analogue on fully developed metaphit seizures, the last two groups were injected after the eight audiogenic testing. The rats were stimulated using electric bell (on the top of the cage, generating 100+/-3 dB and frequency 5-8 kHz, for 60 s) 1 h after metaphit and afterwards at hourly intervals during the experiment. For EEG recordings and power spectra, three gold-plated screws were implanted into the skull. In metaphit-treated animals, EEGs appeared as polyspikes and spike-wave complexes while the power spectra were increasing for 30-h period. The incidence and severity of metaphit-induced audiogenic seizures reached peak value 7-12 h after the injection. Both DSIP and DSIP(1-4) significantly increased power spectra of delta waves and decreased incidence of seizures, mean seizure grade and tonic component of metaphit-induced convulsions. Taken together, these results suggest that DSIP and its analogue DSIP(1-4) should be considered as potential antiepileptics.
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| Authors | Olivera Stanojlović, Dragana Zivanović, Slobodan Mirković, Inessa Mikhaleva |
| Journal | Pharmacology, biochemistry, and behavior (Pharmacol Biochem Behav) Vol. 77 Issue 2 Pg. 227-34 (Feb 2004) ISSN: 0091-3057 [Print] United States |
| PMID | 14751449 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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