Risk modifiers for peripheral sensory neuropathy in HIV infection/AIDS.

Abstract

The objective of this study is to examine the risk factors associated with the development of sensory neuropathy in human immunodeficiency virus (HIV)-infected patients in 292 HIV+ patients recruited through a community-based sentinel survey. We determined the clinical and treatment factors associated with the presence of peripheral sensory neuropathy in HIV+ subjects at baseline examination, and at 1-year follow-up. Baseline examination was assessed with a logistic regression analysis controlling for age, education level, history of drug/alcohol use, and anti-retroviral treatment. The risk of developing new peripheral neuropathy at follow-up was determined using a Cox proportional hazard model analysis. At study entry, neuropathy (n=64) was associated with acquired immunodeficiency syndrome (AIDS), nucleoside analogue reverse transcriptase inhibitors (NRTI) (i.e. ddC), and history of alcohol abuse. After 1-year follow-up, the development of neuropathy was predicted by AIDS, age (older subjects), and NRTI use. These findings indicated that AIDS, age, alcohol abuse/dependence, and anti-retroviral medication use are important predictors of motor/sensory peripheral neuropathy in the HIV infection. The peripheral neurotoxic effect of anti-retroviral medication should be taken into account in the design of long-term therapies.

• Authors: O L Lopez, J T Becker, M-A Dew, R Caldararo
• Journal: European journal of neurology (Eur J Neurol) Vol. 11 Issue 2 Pg. 97-102 (Feb 2004) ISSN: 1351-5101 [Print] England
• PMID: 14748769 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Anti-Retroviral Agents

Topics

• Acquired Immunodeficiency Syndrome (complications, drug therapy)
• Adult
• Anti-Retroviral Agents (adverse effects, therapeutic use)
• Chi-Square Distribution
• Confidence Intervals
• Female
• Follow-Up Studies
• HIV Infections (complications, drug therapy)
• Humans
• Logistic Models
• Male
• Middle Aged
• Odds Ratio
• Peripheral Nervous System Diseases (chemically induced, etiology)
• Proportional Hazards Models
• Risk Factors