Time-dependent anesthetic and anticonvulsant activities of alphaxalone in Syrian hamsters.

Abstract

To assess whether the anesthetic and anticonvulsant activities of alphaxalone display diurnal variability, groups of Syrian hamsters were studied at 4 h-intervals during a 24 h-cycle. The administration of alphaxalone (5 mg/kg) brought about a greater anesthetic activity (loss of righting reflex) at the middle of the photophase. When assessed in hamsters injected with 3-mercaptopropionic acid, alphaxalone displayed maximal anticonvulsant activity at the 4th of darkness. Evaluation of the time needed for first convulsive response indicated that alphaxalone did not show time-dependent effects, while in control hamsters seizure threshold was low during daylight and attained maximal values at night, showing a peak in seizure threshold at light-dark transition.

• Authors: S M Guinjoan, D A Golombek, D P Cardinali
• Journal: Life sciences (Life Sci) Vol. 51 Issue 26 Pg. 2089-95 ( 1992) ISSN: 0024-3205 [Print] Netherlands
• PMID: 1474862 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anesthetics
• Anticonvulsants
• Pregnanediones
• 3-Mercaptopropionic Acid
• alphaxalone

Topics

• 3-Mercaptopropionic Acid (pharmacology)
• Anesthetics (pharmacology)
• Animals
• Anticonvulsants (pharmacology)
• Brain (drug effects)
• Circadian Rhythm (drug effects)
• Cricetinae
• Injections, Intraperitoneal
• Male
• Mesocricetus
• Motor Activity (drug effects)
• Pregnanediones (pharmacology)
• Reflex, Abnormal (drug effects)
• Seizures (drug therapy)