Abstract |
Exogenous ciliary neurotrophic factor ( CNTF) administration causes significant weight loss in both humans and animal models, but the effects of endogenous CNTF and the CNTF null allele on body composition are not fully understood. A recent study in a European cohort demonstrated a significantly higher body weight and body mass index (BMI) in older males homozygous for the CNTF null allele (A/A genotype). We sought to replicate these findings in three cohorts: the Baltimore Longitudinal Study on Aging (BLSA) consisting of 422 adult men and women (19-90 years); the Study of Osteoporotic Risk in Men (STORM) consisting of 333 older men (50-84 years); and a third sample obtained by combining older males aged 59-73 years from the BLSA and STORM cohorts (n=286). In contrast to the European study, we were unable to detect a significant association between CNTF genotype and body weight in the BLSA (P=0.49), the STORM (P=0.28), or the combined samples (P=0.72). There was also no significant association observed between CNTF genotype and BMI in the BLSA (P=0.59), the STORM (P=0.34) or the combined (P=0.56) samples. In addition, we were unable to detect a significant association between CNTF genotype and total body fat (P=0.95) or fat-free mass (P=0.86) in the BLSA cohort. Our results do not support an effect of the CNTF null allele on body composition, contrary to previous findings.
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Authors | Ashok C Jacob, Joseph M Zmuda, Jane A Cauley, E Jeffrey Metter, Ben F Hurley, Robert E Ferrell, Stephen M Roth |
Journal | European journal of human genetics : EJHG
(Eur J Hum Genet)
Vol. 12
Issue 5
Pg. 372-6
(May 2004)
ISSN: 1018-4813 [Print] England |
PMID | 14747836
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Ciliary Neurotrophic Factor
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Analysis of Variance
- Body Constitution
(physiology)
- Body Height
(physiology)
- Body Mass Index
- Body Weight
(physiology)
- Chi-Square Distribution
- Ciliary Neurotrophic Factor
(genetics)
- Cohort Studies
- Female
- Genotype
- Humans
- Male
- Middle Aged
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