Gadolinium-enhanced computed tomography angiography in multi-detector row computed tomography: initial observations.

Abstract

RATIONALE AND OBJECTIVES:

The feasibility of using gadolinium contrast medium for computed tomography angiography (CTA) in multi-detector row computed tomography and the effect of contrast medium dilution was investigated.

MATERIALS AND METHODS:

Three pigs were each scanned in multiple sessions with injections of non-dilute and dilute contrast medium at a dose of 0.3 mmol/kg body weight. Non-spiral dynamic scanning at a fixed mid-abdominal aortic level and thoracoabdominal CTA were performed.

RESULTS:

The magnitude of peak aortic enhancement was not significantly different between dilute and non-dilute contrast medium injections (P = .88), but the former showed earlier enhancement (mean of 2.3 seconds sooner, P < .01) than the latter. CT angiography with gadolinium contrast medium showed much lower enhancement than iodine contrast medium, but small vessels were readily identifiable.

CONCLUSION:

Gadolinium contrast medium combined with multi-detector row computed tomography may provide clinically useful CTA. Dilution of contrast medium shortens the enhancement time but has little effect on the magnitude.

• Authors: Kyongtae T Bae, Ronan McDermott, David S Gierada, Jay P Heiken, Mark A Nolte, Naoki Takahashi, Cheng Hong
• Journal: Academic radiology (Acad Radiol) Vol. 11 Issue 1 Pg. 61-8 (Jan 2004) ISSN: 1076-6332 [Print] United States
• PMID: 14746403 (Publication Type: Comparative Study, Evaluation Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Iodine Radioisotopes
• Radioisotopes
• Gadolinium

Topics

• Angiography
• Animals
• Contrast Media
• Feasibility Studies
• Gadolinium
• Injections, Intravenous
• Iodine Radioisotopes
• Models, Animal
• Radiographic Image Enhancement
• Radiographic Image Interpretation, Computer-Assisted
• Radioisotopes
• Swine
• Time Factors
• Tomography, X-Ray Computed