Inhibition of Neisseria gonorrhoeae genital tract infection by leading-candidate topical microbicides in a mouse model.

Abstract	The development of effective vaginal microbicides is paramount in the fight against the spread of sexually transmitted infections. Preclinical testing of candidate microbicides for the prevention of gonorrhea has been seriously hindered by the lack of an animal model. We assessed the efficacy of 7 promising formulated agents--CarraGuard, Ushercell, [poly]sodium 4-styrene sulfonate (T-PSS), PRO 2000, ACIDFORM, cellulose acetate phthalate (CAP), and BufferGel--by use of a mouse model of Neisseria gonorrhoeae genital tract infection. Mice received test agent, relevant placebo, or no treatment, followed by intravaginal N. gonorrhoeae challenge. N. gonorrhoeae colonization was tested by vaginal culture. CarraGuard, Ushercell, and T-PSS demonstrated significant protection, compared with control agents and no treatment. PRO 2000, ACIDFORM, and CAP showed significant protection, compared with no treatment but not compared with respective control agents. Mice that received BufferGel were provided significant protection, compared with untreated control mice; no placebo was tested. The findings of the present study suggest that topical agents may effectively reduce N. gonorrhoeae infection and that further evaluation is warranted.
Authors	Steven E Spencer, Iris E Valentin-Bon, Kevin Whaley, Ann E Jerse
Journal	The Journal of infectious diseases (J Infect Dis) Vol. 189 Issue 3 Pg. 410-9 (Feb 01 2004) ISSN: 0022-1899 [Print] United States
PMID	14745698 (Publication Type: Comparative Study, Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References	Acrylic Resins Anti-Infective Agents, Local BufferGel Gels Naphthalenesulfonates PRO 2000 Polymers Polystyrenes Spermatocidal Agents polystyrene sulfonic acid
Topics	Acrylic Resins Animals Anti-Infective Agents, Local (pharmacology, therapeutic use) Disease Models, Animal Female Gels (therapeutic use) Gonorrhea (drug therapy, microbiology) Mice Mice, Inbred BALB C Microbial Sensitivity Tests Naphthalenesulfonates (therapeutic use) Neisseria gonorrhoeae (drug effects) Polymers (therapeutic use) Polystyrenes (therapeutic use) Spermatocidal Agents (therapeutic use) Vagina (microbiology)

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