Abstract | BACKGROUND:
Serotonin 5-HT(2A) receptors play an important role in the regulation of many functions that are disturbed in patients with major depressive disorder. Postmortem and positron emission tomography studies have reported both increased and decreased 5-HT(2A) receptor binding in different limbic and paralimbic regions. METHODS: RESULTS:
5-HT(2A) receptor binding in the hippocampus was reduced by 29% in depressed subjects (p =.004). In other regions, 5-HT(2A) receptor binding was decreased (averaging 15%) but not significantly. Both groups had similar age-dependent decreases in 5-HT(2A) receptors throughout all brain regions. CONCLUSIONS: Altered serotoninergic function in the hippocampus is likely involved in the disturbances of mood regulation in major depressive disorder, although the specific role of the 5-HT(2A) receptor changes is still unclear.
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Authors | Mark A Mintun, Yvette I Sheline, Stephen M Moerlein, Andrei G Vlassenko, Yiyun Huang, Abraham Z Snyder |
Journal | Biological psychiatry
(Biol Psychiatry)
Vol. 55
Issue 3
Pg. 217-24
(Feb 01 2004)
ISSN: 0006-3223 [Print] United States |
PMID | 14744461
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Fluorine Radioisotopes
- Receptor, Serotonin, 5-HT2A
- altanserin
- Ketanserin
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Topics |
- Adult
- Age Factors
- Aged
- Aged, 80 and over
- Case-Control Studies
- Depressive Disorder, Major
(diagnostic imaging, metabolism)
- Female
- Fluorine Radioisotopes
- Hippocampus
(diagnostic imaging, metabolism)
- Humans
- Ketanserin
(analogs & derivatives)
- Male
- Middle Aged
- Receptor, Serotonin, 5-HT2A
(metabolism)
- Tomography, Emission-Computed
(methods)
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