Abstract | BACKGROUND: Desmosomal proteins are well established markers of epithelial differentiation. Down-regulation of desmosomal proteins has been suggested to be a sign of reduced adhesiveness in metastasizing cells. METHODS: RESULTS: CONCLUSIONS: Desmosomal proteins are highly regulated in cutaneous SCC. Only desmoglein 2 expression correlates with risk of metastasis. Desmosomes may still be functional in metastasizing tumor cells.
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Authors | Hjalmar Kurzen, Ivonne Münzing, Wolfgang Hartschuh |
Journal | Journal of cutaneous pathology
(J Cutan Pathol)
Vol. 30
Issue 10
Pg. 621-30
(Nov 2003)
ISSN: 0303-6987 [Print] United States |
PMID | 14744087
(Publication Type: Journal Article)
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Chemical References |
- Cytoskeletal Proteins
- DSG1 protein, human
- DSG2 protein, human
- DSP protein, human
- Desmocollins
- Desmoglein 1
- Desmoglein 2
- Desmogleins
- Desmoplakins
- Membrane Proteins
- PKP1 protein, human
- PKP2 protein, human
- Plakophilins
- Protein Isoforms
- Proteins
- gamma Catenin
- Racemases and Epimerases
- NDP-4-keto-6-deoxy-D-glucose 3',5'-epimerase
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Topics |
- Bowen's Disease
(metabolism)
- Carcinoma, Squamous Cell
(metabolism)
- Cytoskeletal Proteins
(metabolism)
- Desmocollins
- Desmoglein 1
- Desmoglein 2
- Desmogleins
- Desmoplakins
- Desmosomes
(metabolism)
- Epidermis
(metabolism)
- Humans
- Immunohistochemistry
- Keratosis
(metabolism)
- Membrane Proteins
(metabolism)
- Plakophilins
- Protein Isoforms
(metabolism)
- Proteins
(metabolism)
- Racemases and Epimerases
- Skin Neoplasms
(metabolism)
- gamma Catenin
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