[Synthesis and antiviral activity of ureides and carbamates of betulinic acid and its derivatives].

Abstract

Ureides and carbamates of betulinic acid and its derivatives were prepared in good yields by interaction of betulinic acid, betulonic acid, and betulonic acid 3-oxime with amines, amino acids, and alcohols. Ureides of betulonic acid containing L-Val and L-Met residues were found to be effective against herpes simplex type 1 virus. The English version of the paper: Russian Journal of Bioorganic Chemistry, 2003, vol. 29, no. 6; see also http://www.maik.ru.

• Authors: O B Flekhter, E I Boreko, L R Nigmatullina, E V Tret'iakova, N I Pavlova, L A Baltina, S N Nikolaeva, O V Savinova, F Z Galin, G A Tolstikov
• Journal: Bioorganicheskaia khimiia (Bioorg Khim) 2003 Nov-Dec Vol. 29 Issue 6 Pg. 655-61 ISSN: 0132-3423 [Print] Russia (Federation)
• Vernacular Title: Sintez i protivovirusnaia aktivnost' ureidov i karbamatov betulinovoĭ kisloty i ee proizvodnykh.
• PMID: 14743541 (Publication Type: Journal Article)

Chemical References

• Antiviral Agents
• Carbamates
• Pentacyclic Triterpenes
• Triterpenes
• Betulinic Acid

Topics

• Antiviral Agents (chemical synthesis, pharmacology)
• Carbamates (chemical synthesis, pharmacology)
• Magnetic Resonance Spectroscopy
• Pentacyclic Triterpenes
• Spectrophotometry, Infrared
• Triterpenes (chemical synthesis, pharmacology)
• Betulinic Acid