Abstract | OBJECTIVES: RESEARCH METHODS AND PROCEDURES: 11beta-HSD gene expression in subcutaneous adipose tissue biopsies of 70 postmenopausal women was studied by real-time reverse-transcription polymerase chain reaction. The influence of weight reduction and in vitro effects of several modulators of adipocyte gene expression on 11beta-HSD genes in human adipocytes were also studied. RESULTS: DISCUSSION: Our data suggest that increased expression of the 11beta-HSD1 gene is associated with metabolic abnormalities in obese women and that increased expression of this gene may contribute to the previously reported increased local conversion of cortisone to cortisol in adipose tissue of obese individuals.
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Authors | Stefan Engeli, Jana Böhnke, Mareike Feldpausch, Kerstin Gorzelniak, Ute Heintze, Jürgen Janke, Friedrich C Luft, Arya M Sharma |
Journal | Obesity research
(Obes Res)
Vol. 12
Issue 1
Pg. 9-17
(Jan 2004)
ISSN: 1071-7323 [Print] United States |
PMID | 14742837
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- RNA, Messenger
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
- Hydrocortisone
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Topics |
- 11-beta-Hydroxysteroid Dehydrogenase Type 1
(genetics)
- Adipocytes
(enzymology)
- Adipose Tissue
(enzymology)
- Aged
- Body Constitution
- Cross-Sectional Studies
- Female
- Gene Expression Regulation, Enzymologic
(drug effects)
- Homeostasis
- Humans
- Hydrocortisone
(pharmacology)
- Insulin Resistance
- Middle Aged
- Obesity
(enzymology, therapy)
- Postmenopause
- RNA, Messenger
(analysis)
- Weight Loss
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