Condom effectiveness for reducing transmission of gonorrhea and chlamydia: the importance of assessing partner infection status.

Abstract

This analysis examined the importance of differential exposure to infected partners in epidemiologic studies of latex condom effectiveness for prevention of sexually transmitted infections. Cross-sectional, enrollment visit data were analyzed from Project RESPECT, a trial of counseling interventions conducted at five publicly funded US sexually transmitted disease clinics between 1993 and 1997. The association between consistent condom use in the previous 3 months and prevalent gonorrhea and chlamydia (Gc/Ct) was compared between participants known to have infected partners and participants whose partner infection status was unknown. Among 429 participants with known Gc/Ct exposure, consistent condom use was associated with a significant reduction in prevalent gonorrhea and chlamydia (30% vs. 43%; adjusted prevalence odds ratio = 0.42, 95% confidence interval: 0.18, 0.99). Among 4,314 participants with unknown Gc/Ct exposure, consistent condom use was associated with a lower reduction in prevalent gonorrhea and chlamydia (24% vs. 25%; adjusted prevalence odds ratio = 0.82, 95% confidence interval: 0.66, 1.01). The number of unprotected sex acts was significantly associated with infection when exposure was known (p for trend < 0.01) but not when exposure was unknown (p for trend = 0.73). Restricting analyses to participants with known exposure to infected partners provides a feasible and efficient mechanism for reducing confounding from differential exposure to infected partners in condom effectiveness studies.

• Authors: Lee Warner, Daniel R Newman, Harland D Austin, Mary L Kamb, John M Douglas Jr, C Kevin Malotte, Jonathan M Zenilman, Judy Rogers, Gail Bolan, Martin Fishbein, David G Kleinbaum, Maurizio Macaluso, Thomas A Peterman, Project RESPECT Study Group
• Journal: American journal of epidemiology (Am J Epidemiol) Vol. 159 Issue 3 Pg. 242-51 (Feb 01 2004) ISSN: 0002-9262 [Print] United States
• PMID: 14742284 (Publication Type: Journal Article)

Topics

• Adult
• Chlamydia Infections (epidemiology, prevention & control, transmission)
• Condoms (statistics & numerical data)
• Educational Status
• Female
• Gonorrhea (epidemiology, prevention & control, transmission)
• Humans
• Logistic Models
• Male
• Sexual Behavior (statistics & numerical data)
• United States (epidemiology)