Safety and efficacy of antimicrobial peptides against naturally acquired leishmaniasis.

Abstract

Leishmaniases, which are important causes of morbidity and mortality in humans and dogs, are extremely difficult to treat. Antimicrobial peptides are rarely used as alternative treatments for naturally acquired parasitic diseases. Here we report that the acylated synthetic antimicrobial peptide Oct-CA(1-7)M(2-9) is safe and effective for treating naturally acquired canine leishmaniasis.

• Authors: J Alberola, A Rodríguez, O Francino, X Roura, L Rivas, D Andreu
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 48 Issue 2 Pg. 641-3 (Feb 2004) ISSN: 0066-4804 [Print] United States
• PMID: 14742227 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents
• Antimicrobial Cationic Peptides
• octyl-cecropin(1-7)melittin(2-9)

Topics

• Animals
• Anti-Infective Agents (adverse effects, therapeutic use)
• Antimicrobial Cationic Peptides (adverse effects, therapeutic use)
• Dog Diseases (drug therapy, parasitology)
• Dogs
• Leishmania infantum
• Leishmaniasis, Visceral (drug therapy, parasitology, veterinary)