Abstract |
Tumor imaging with cis-4-[18F]fluoro- L-proline ( cis-FPro) was compared to that of L-[3H] proline and L-[3H] methionine in F98 rat gliomas by dual-tracer autoradiography. All tracers exhibited high accumulation in the tumors but in the normal brain significant uptake was observed for L-[3H] methionine only. Tumor extent on autoradiograms with L-[3H] proline and L-[3H] methionine was identical to that of histological staining while autoradiograms of cis-FPro showed diffuse uptake in the penumbra of some tumors. First PET studies in 7 patients with cerebral gliomas demonstrated accumulation of cis-FPro in tumor areas with enhancement of Gd-DTPA on MR scans. Uptake of cis-FPro in normal brain tissue was negligible. In one patient with a glioblastoma accumulation of cis-FPro was also found in two brain areas without enhancement of Gd-DTPA on MR scans. Control of MRI suggested tumor growth in these areas at further follow up. Our results indicate that in most gliomas increased cis-FPro uptake is restricted to areas with disruption of the BBB which limits its clinical utility.
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Authors | Karl J Langen, Michael Jarosch, Kurt Hamacher, Heinz Mühlensiepen, Friedrich Weber, Frank Floeth, Dirk Pauleit, Hans Herzog, Heinz H Coenen |
Journal | Nuclear medicine and biology
(Nucl Med Biol)
Vol. 31
Issue 1
Pg. 67-75
(Jan 2004)
ISSN: 0969-8051 [Print] United States |
PMID | 14741571
(Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Validation Study)
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Chemical References |
- Radiopharmaceuticals
- fluoro-proline
- Proline
- Methionine
- methionine methyl ester
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Topics |
- Adult
- Animals
- Autoradiography
- Brain Neoplasms
(diagnosis, diagnostic imaging)
- Cell Line, Tumor
- Female
- Glioma
(diagnosis, diagnostic imaging)
- Humans
- Male
- Methionine
(analogs & derivatives)
- Middle Aged
- Proline
(analogs & derivatives)
- Radiopharmaceuticals
- Rats
- Rats, Inbred F344
- Reproducibility of Results
- Sensitivity and Specificity
- Tomography, Emission-Computed
(methods)
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