TMC-95A, a reversible proteasome inhibitor, induces neurite outgrowth in PC12 cells.

Abstract

TMC-95A has been characterized as a potent proteasome inhibitor that binds to enzymes non-covalently at low nanomolar concentrations. Herein, the neuritogenic activity of TMC-95A in PC12 rat pheochromocytoma cells is reported for the first time. TMC-95A induced a positive neurite initiation of PC12 cells at concentration ranging from 1 to 20 microM.

• Authors: Masayuki Inoue, Haifeng Zhai, Hayato Sakazaki, Hidetomo Furuyama, Yoshiyasu Fukuyama, Masahiro Hirama
• Journal: Bioorganic & medicinal chemistry letters (Bioorg Med Chem Lett) Vol. 14 Issue 3 Pg. 663-5 (Feb 09 2004) ISSN: 0960-894X [Print] England
• PMID: 14741264 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Multienzyme Complexes
• Peptides, Cyclic
• Protease Inhibitors
• TMC-95A
• Cysteine Endopeptidases
• Proteasome Endopeptidase Complex

Topics

• Animals
• Ascomycota (chemistry)
• Cysteine Endopeptidases (drug effects)
• Molecular Structure
• Multienzyme Complexes (drug effects)
• Neurites (drug effects, physiology)
• PC12 Cells
• Peptides, Cyclic (isolation & purification, pharmacology)
• Protease Inhibitors (isolation & purification, pharmacology)
• Proteasome Endopeptidase Complex
• Rats