Prior DNA vaccination does not interfere with the live-attenuated measles vaccine.

Abstract

The currently used live-attenuated measles vaccine is very effective although maternal antibody prevents its administration prior to 6 months of age. We are investigating the ability of a DNA vaccine encoding the measles viral hemagglutinin, fusion and nucleoprotein to protect newborn infants from measles. Here, we show that a measles DNA vaccine protects juvenile macaques from pathogenic measles virus challenge and that macaques primed and boosted with this DNA vaccine have anemnestic antibody and cell-mediated responses after vaccination with a live-attenuated canine distemper-measles vaccine. Therefore, this DNA vaccine administered to newborn infants may not hinder the subsequent use of live-attenuated measles vaccine.

• Authors: Mary Premenko-Lanier, Paul Rota, Gary Rhodes, William Bellini, Michael McChesney
• Journal: Vaccine (Vaccine) Vol. 22 Issue 5-6 Pg. 762-5 (Jan 26 2004) ISSN: 0264-410X [Print] Netherlands
• PMID: 14741170 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Measles Vaccine
• Vaccines, Attenuated
• Vaccines, DNA

Topics

• Animals
• Humans
• Immunologic Memory
• Infant
• Infant, Newborn
• Injections, Subcutaneous
• Macaca mulatta
• Measles Vaccine (administration & dosage, immunology)
• Neutralization Tests
• Vaccines, Attenuated (administration & dosage, immunology)
• Vaccines, DNA (administration & dosage, immunology)