Abstract |
Human endogenous retroviruses (HERVs) expression has been suspected as a factor participating in the development of autoimmune diseases. Employing the dot blot hybridisation, we observed that 90.9% of mixed connective tissue disease ( MCTD) (n = 22) patients exhibited the presence of human immunodeficiency virus type 1 (HIV-1) conserved pol sequence in DNA isolated from serum. The same investigation conducted in the group of systemic sclerosis (SSc) (n = 79) patients identified a conserved retroviral pol sequence in 34.6% of antinuclear antibodies (ANA) positive (n = 52) and 40.7% of ANA negative (n = 27) patients. However, 100% of anti-U1-ribonucleoprotein (RNP) positive SSc (n = 9) patients exhibited the presence of HIV-1 conserved pol sequence. Our findings suggest that the presence of retroviral sequence in serum of MCTD and SSc patients may correlate with development of autoimmune response directed against U1-70 kDa polypeptide antigen.
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Authors | Janusz Prokop, Pawel P Jagodzinski |
Journal | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
(Biomed Pharmacother)
Vol. 58
Issue 1
Pg. 61-4
(Jan 2004)
ISSN: 0753-3322 [Print] France |
PMID | 14739063
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antibodies, Antinuclear
- Autoantigens
- Gene Products, pol
- Nuclear Proteins
- Ribonucleoprotein, U1 Small Nuclear
- Scl 70 antigen, human
- DNA Topoisomerases, Type I
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Topics |
- Antibodies, Antinuclear
(blood)
- Autoantigens
(immunology)
- Conserved Sequence
- DNA Topoisomerases, Type I
- Female
- Gene Products, pol
(blood, genetics)
- HIV-1
(enzymology, genetics)
- Humans
- Male
- Mixed Connective Tissue Disease
(blood, enzymology, genetics)
- Nuclear Proteins
(immunology)
- Ribonucleoprotein, U1 Small Nuclear
(immunology)
- Scleroderma, Systemic
(blood, enzymology, genetics)
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