Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES.

Abstract

Antiangiogenic activity has been identified in an aqueous EtOH extract of Rabdosia rubescens, a component of the dietary supplement PC SPES. Bioassay-guided fractionation using a novel in vitro human endothelial cell-based assay for angiogenesis afforded the diterpenoids ponicidin (1) and oridonin (2), with significant antiangiogenic activity at subcytotoxic concentrations, suggesting that these constituents may strongly contribute to the demonstrated clinical efficacy of PC SPES as a treatment for advanced prostate cancer.

• Authors: Linda C Meade-Tollin, E M Kithsiri Wijeratne, Deborah Cooper, Mischa Guild, Edlyn Jon, Anne Fritz, Guang-Xiong Zhou, Luke Whitesell, Jing-Yu Liang, A A Leslie Gunatilaka
• Journal: Journal of natural products (J Nat Prod) Vol. 67 Issue 1 Pg. 2-4 (Jan 2004) ISSN: 0163-3864 [Print] United States
• PMID: 14738375 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Angiogenesis Inhibitors
• Antineoplastic Agents, Phytogenic
• Diterpenes
• Diterpenes, Kaurane
• Drugs, Chinese Herbal
• herbal preparation PC-SPES
• oridonin
• ponicidin

Topics

• Angiogenesis Inhibitors (therapeutic use)
• Antineoplastic Agents, Phytogenic (therapeutic use)
• Cells, Cultured
• Diterpenes (pharmacology)
• Diterpenes, Kaurane
• Drugs, Chinese Herbal (therapeutic use)
• Endothelial Cells (drug effects)
• Humans
• Hydrolysis
• Inhibitory Concentration 50
• Isodon (chemistry)
• Male
• Molecular Structure
• Prostatic Neoplasms (drug therapy)