HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Use of intravenous anti-D in patients with refractory and relapsed immune thrombocytopenic purpura.

AbstractOBJECTIVE:
To determine the response to i.v. anti-D and its comparison with splenectomy as second line therapy in refractory and relapsed cases of ITP, in the Aga Khan University Hospital, Karachi.
METHODS:
A total of 23 patients with chronic ITP were treated with either anti-D or splenectomy as second line treatment. The patients were assessed for time to achieve a response to second line treatment, duration of response and adverse events.
RESULTS:
There were 12 patients in the anti-D group and 11 in the splenectomy group. The mean platelet count at presentation was 9,000/cumm. The mean age was 8.9 years and 13.0 years and the male to female ratio was 1:1 and 1:1.2 in anti-D and splenectomy group respectively. 54.5% of the patient in the anti-D group responded compared to 81.8% in the splenectomy group. Median time to achieve a response was 7 days in the anti-D group and 1 day in the splenectomy group. Mean time to relapse was 87.8 days in the anti-D group and 55.4 days in the splenectomy group. No adverse events were recorded for any of the infusions of anti-D and none of the patients had more than 0.5 gm/dl fall in the hemoglobin level following anti-D infusion.
CONCLUSION:
It was thus concluded that Anti-D is a relatively safe, convenient and effective therapy for chronic ITP and can be used as a splenectomy sparing agent when treatment is clinically indicated.
AuthorsR Sajid, S N Adil, Z Fadoo, S Sabir, M Khurshid
JournalJPMA. The Journal of the Pakistan Medical Association (J Pak Med Assoc) Vol. 53 Issue 11 Pg. 537-9 (Nov 2003) ISSN: 0030-9982 [Print] Pakistan
PMID14738260 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)
Chemical References
  • Isoantibodies
  • RHO(D) antibody
  • Rho(D) Immune Globulin
Topics
  • Adolescent
  • Child
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Isoantibodies
  • Male
  • Pakistan
  • Purpura, Thrombocytopenic (immunology, surgery, therapy)
  • Recurrence
  • Reproducibility of Results
  • Rho(D) Immune Globulin (therapeutic use)
  • Splenectomy
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: