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[Improvement of action myoclonus in a patient with dentatorubral-pallidoluysian atrophy by piracetam].

Abstract
We report a 13-year-old girl with dentatorubal-pallidoluysian atrophy (DRPLA), presenting clinically as progressive myoclonic epilepsy. The action myoclonus, which severely impaired her daily life, was markedly improved by administration of piracetam, a drug reportedly useful for myoclonus of cortical origin. In our case, piracetam effectively suppressed severe subcortical myoclonus of DRPLA, suggesting that the drug may be useful in the treatment of both cortical, and subcortical myoclonus.
AuthorsMieko Hirose, Hiroyuki Yokoyama, Rie Noguchi, Kazuhiro Haginoya, Masashi Aoki, Kazuie Iinuma
JournalNo to hattatsu = Brain and development (No To Hattatsu) Vol. 36 Issue 1 Pg. 75-9 (Jan 2004) ISSN: 0029-0831 [Print] Japan
PMID14737869 (Publication Type: Case Reports, English Abstract, Journal Article)
Chemical References
  • Neuroprotective Agents
  • Piracetam
Topics
  • Adolescent
  • Cerebral Cortex
  • Female
  • Humans
  • Myoclonic Epilepsies, Progressive (complications, drug therapy, etiology)
  • Neuroprotective Agents (therapeutic use)
  • Piracetam (therapeutic use)
  • Treatment Outcome

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