HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Therapeutic effect of heme arginate in myelodysplastic syndromes.

Abstract
In order to investigate, whether heme would induce a response in myelodysplastic syndromes (MDS), 14 symptomatic patients (4 RA, 3 RARS and 7 RAEB) were treated with infusions of heme arginate 3 mg/kg body weight on 4 consecutive days, mostly for six cycles at 2-week intervals. Three of 14 patients (21%) showed an improvement in anemia (97-152, 79-120 and 92-114 g/l) within a few weeks, and 1 showed a milder increase in hemoglobin level (102-118 g/l). Of the 2 responders with marked thrombocytopenia, 1 showed an improvement in the platelet count (7-37 x 10(9)/l) and her regular need for red cell and platelet transfusions ceased. Some regression in bone marrow (BM) cytology was seen in all 3 responders. One of the responders is still in remission 41 months after cessation of the treatment, while in the other 2 the response lasted for 26 and 5 months. Four patients progressed during the treatment: 1 RA to RAEB, 1 RAEB to RAEBt and 2 RAEB, both with very complex chromosomal abnormalities at the beginning of the therapy, to acute erythroleukemia (AML-M6). Pretreatment delta-aminolevulinic acid synthase and heme synthase activities were generally low. Five patients had mild thrombophlebitis, but not after the infusion procedure was changed. No other side-effects common to growth factors occurred. In conclusion, it is likely that heme arginate has a therapeutic effect on some MDS patients, obviously by stimulating erythropoiesis. The response may be long-lasting.
AuthorsT T Timonen, H Kauma
JournalEuropean journal of haematology (Eur J Haematol) Vol. 49 Issue 5 Pg. 234-8 (Nov 1992) ISSN: 0902-4441 [Print] DENMARK
PMID1473585 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Erythropoietin
  • Heme
  • Arginine
  • Creatinine
  • Aspartate Aminotransferases
  • Alanine Transaminase
  • heme arginate
Topics
  • Adult
  • Aged
  • Alanine Transaminase (blood)
  • Arginine (adverse effects, therapeutic use)
  • Aspartate Aminotransferases (blood)
  • Bone Marrow (pathology)
  • Creatinine (blood)
  • Erythropoietin (blood)
  • Female
  • Heme (adverse effects, therapeutic use)
  • Humans
  • Karyotyping
  • Male
  • Middle Aged
  • Myelodysplastic Syndromes (blood, drug therapy, pathology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: