Abstract | RATIONALE AND OBJECTIVES: METHODS: Twelve male rats received N-nitrosomorpholine solution as drinking water to induce hepatic tumors. After injection of Gd-EOB-DTPA, rats were subjected to dynamic and delayed MRI. The relative enhancement (RE) was calculated, and the time of the maximum RE (Tmax) was evaluated. After MRI, liver was histologically analyzed. RESULTS: One hundred sixty-three hepatic tumors 3-12 mm in diameter were induced after 18 weeks of treatment with 0.01 wt/vol% of N-nitrosomorpholine, and 81 of them were evaluated. The RE in hyperplastic nodules ( HPNs) was significantly higher than that in moderately or poorly differentiated hepatocellular carcinomas (HCCs) in the late phase, whereas there was no significant difference in RE between well-differentiated HCCs and HPNs. The average Tmax in HPNs was about 13 minutes, whereas that of each differentiated HCCs was about 1 minute. CONCLUSIONS: It was possible to differentiate benign HPNs and malignant HCCs (especially well-differentiated HCCs) by evaluating the change of RE or comparison of Tmax with Gd-EOB-DTPA-enhanced MRI.
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Authors | Natsuko Tsuda, Naoki Kato, Chie Murayama, Michiko Narazaki, Takashi Yokawa |
Journal | Investigative radiology
(Invest Radiol)
Vol. 39
Issue 2
Pg. 80-8
(Feb 2004)
ISSN: 0020-9996 [Print] United States |
PMID | 14734922
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- gadolinium ethoxybenzyl DTPA
- Gadolinium DTPA
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Topics |
- Animals
- Contrast Media
- Diagnosis, Differential
- Disease Models, Animal
- Gadolinium DTPA
- Image Enhancement
- Liver Neoplasms
(diagnosis)
- Liver Neoplasms, Experimental
(diagnosis)
- Magnetic Resonance Imaging
(methods)
- Male
- Rats
- Time Factors
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