Abstract | OBJECTIVE: METHODS: RESULTS: At baseline, EMAP II protein and mRNA are minimally expressed with transcription products localizing predominately to the perivascular stroma region in the normal rat myocardium. Six hours following myocardial infarction, EMAP II changes its distribution from the perivascular stroma to an invading inflammatory cell population. This is associated with a 2-fold (P < 0.0009) increase in EMAP II protein and its transcription primarily localized to the infarct region. EMAP II protein expression remains elevated throughout the weeks following the infarction with transcription limited to the infarct region and a notable decrease in EMAP II transcription products noted in the viable vasculature surrounding the infarct zone. Six weeks following myocardial infarction, EMAP II protein is elevated above control, changes its location of transcription from the inflammatory cell population to that of the fibroblasts located in the relative avascular scar tissue, and has resumed its perivascular stromal distribution in the viable periinfarct tissue. CONCLUSIONS: Thus, the temporospatial distribution of this antiangiogenic protein suggests that negative vascular modulators may have a function in the revascularization process following acute myocardial infarction.
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Authors | Jess L Thompson, James A Ryan, Mark L Barr, Benjamin Franc, Vaughn A Starnes, Margaret A Schwarz |
Journal | The Journal of surgical research
(J Surg Res)
Vol. 116
Issue 1
Pg. 156-64
(Jan 2004)
ISSN: 0022-4804 [Print] United States |
PMID | 14732363
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Angiogenesis Inhibitors
- Cytokines
- Neoplasm Proteins
- RNA, Messenger
- RNA-Binding Proteins
- small inducible cytokine subfamily E, member 1
|
Topics |
- Angiogenesis Inhibitors
(metabolism)
- Animals
- Cytokines
(genetics, metabolism)
- Fibroblasts
(metabolism)
- Male
- Myocardial Infarction
(metabolism, pathology, physiopathology)
- Myocardium
(metabolism)
- Neoplasm Proteins
(genetics, metabolism)
- Pericytes
(metabolism)
- RNA, Messenger
(metabolism)
- RNA-Binding Proteins
(genetics, metabolism)
- Rats
- Rats, Sprague-Dawley
- Tissue Distribution
- Wound Healing
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