Assessment of efficacy of quercetin-5'-sulfonic acid sodium salt in the treatment of acute chromium poisoning: experimental studies.

Abstract

Hexavalent chromium compounds exhibit higher toxicity than its trivalent compounds since chromium ions in the +6 oxidation state easily cross biological membranes. It has recently been proposed that substances reducing chromium ions from the +6 to the less toxic +3 oxidation state can be beneficial in management of acute chromium poisoning. In vitro studies also demonstrated quercetin-5 '-sulfonic acid sodium salt (NaQSA) to reduce chromium ions from the +6 to the +3 oxidation state. The aim of the study was to determine efficacy of NaQSA in treatment of acute poisoning with a hexavalent chromium compound. The experiment was carried out on male and female Wistar rats which were divided into 4 experimental (A,B,C,D) and control (K) groups. All animals received intragastrically a single CrO3 dose equal to its LD50. Thirty minutes after administration of CrO3, NaQSA was administered intragastrically at a dose of 50 mg/kg (group A) and 100 mg/kg (group B). In groups C and D, NaQSA was administered ip 2 h after administration of CrO3 and then twice a day for 4 days at doses of 50 mg/kg (group C) and 100 mg/kg (group D). Only intragastric administration of NaQSA at a dose of 100 mg/kg decreased mortality in acute poisoning with CrO3. In groups B and D, aminotransferase activity was statistically significantly dropping from day 7 of the experiment in comparison with the group K, which indicates lesser damage to the liver in animals treated with NaQSA. Bilirubin concentrations in groups B and D were also much lower than in the group K, but the difference between average bilirubin levels in these groups and the K was not statistically significant. The results of the study suggest the usefulness of NaQSA in the treatment of poisoning with hexavalent chromium compounds.

• Authors: Adam Szelag, Jan Magdalan, Maria Kopacz, Anna Kuźniar, Przemysław Kowalski, Małgorzata Pieśniewska
• Journal: Polish journal of pharmacology (Pol J Pharmacol) 2003 Nov-Dec Vol. 55 Issue 6 Pg. 1097-103 ISSN: 1230-6002 [Print] Poland
• PMID: 14730106 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Antidotes
• Chromium Compounds
• chromium trioxide
• Quercetin

Topics

• Acute Disease
• Animals
• Antidotes (therapeutic use)
• Chromium Compounds (blood, poisoning)
• Dose-Response Relationship, Drug
• Female
• In Vitro Techniques
• Injections, Intraperitoneal
• Male
• Poisoning (drug therapy, mortality, pathology)
• Quercetin (analogs & derivatives, therapeutic use)
• Rats
• Rats, Wistar