| Abstract | Fourteen cases of chronic lymphocytic leukaemia (CLL) and massive splenomegaly associated with anaemia and/or thrombocytopenia (stage C) with or without mechanical distress underwent splenectomy. Eleven regressed to stage A and 2 to stage B. All 6 patients with mechanical distress were relieved of their symptoms. Among 13 patients with anaemia, haemoglobin (Hb) level was normalised in 3, improved in 8 and showed no change in 2 cases. Among 13 patients with thrombocytopenia, platelet count was normalised in 10, improved in 1 and was unchanged in 2 cases. Mean Hb level increased from 89 g/l to 125 g/l and mean platelet count from 77 x 10(9)/l to 241 x 10(9)/l (p < 0.001 for both). Duration of response lasted for a mean period of 42.1 (CI 20.8-63.5) months. Mean survival after splenectomy was 44.5 months (CI 21.2-67.7). There was no operative mortality but 4 patients had significant post-operative morbidity. It is concluded that splenectomy is beneficial in advanced cases of CLL with massive splenomegaly and cytopenia. |
| Authors | G Majumdar, A K Singh
(Affiliation: Division of Haematology, UMDS, St. Thomas' Campus, London, England.)
|
| Journal | Leukemia & lymphoma
(Leuk Lymphoma)
Vol. 7
Issue 1-2
Pg. 131-4
(May 1992)
ISSN: 1042-8194 SWITZERLAND |
| PMID | 1472923
(Publication Type: Journal Article)
|
| Chemical References |
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| Topics |
- Anemia
(etiology)
- Female
- Hemoglobins
(analysis)
- Humans
- Leukemia, Lymphocytic, Chronic, B-Cell
(blood, complications, pathology, surgery)
- Leukocyte Count
- Male
- Middle Aged
- Neoplasm Staging
- Platelet Count
- Splenectomy
- Splenomegaly
(etiology, pathology)
- Thrombocytopenia
(etiology)
|
