Bupropion SR in adolescents with comorbid ADHD and nicotine dependence: a pilot study.

Abstract

OBJECTIVE:

Bupropion SR has been shown to be effective for the treatment of nicotine dependence in adults. This open-label pilot study was designed to examine the feasibility and preliminary tolerability of bupropion SR in adolescents with nicotine dependence.

METHOD:

Sixteen adolescents aged 12 to 19 years were enrolled in the study. Eleven of the 16 participants also had comorbid attention-deficit/hyperactivity disorder (ADHD). Participants were titrated over 1 week to bupropion SR 150 mg b.i.d. and maintained at this dosage for 6 weeks. Participants also received two brief smoking cessation counseling sessions.

RESULTS:

Nine participants received at least 4 weeks of medication. There was a significant decrease in the average number of cigarettes smoked (p <.00) and carbon monoxide levels (p =.04) over the course of treatment. Intent-to-treat analysis showed that 31.25% of the adolescents were completely abstinent (5/16) after 4 weeks of taking bupropion SR. Participants' weight did not change significantly during the study (p =.55). There was a no significant change in ADHD symptoms during the study (p =.1).

CONCLUSIONS:

Bupropion SR along with brief counseling may be safe and potentially efficacious for adolescents with nicotine dependence with and without ADHD. Smoking cessation trials in adolescents need to focus on strategies to increase retention for optimal effect.

• Authors: Himanshu P Upadhyaya, Kathleen T Brady, Wei Wang
• Journal: Journal of the American Academy of Child and Adolescent Psychiatry (J Am Acad Child Adolesc Psychiatry) Vol. 43 Issue 2 Pg. 199-205 (Feb 2004) ISSN: 0890-8567 [Print] United States
• PMID: 14726727 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Dopamine Uptake Inhibitors
• Bupropion

Topics

• Adolescent
• Attention Deficit Disorder with Hyperactivity (complications, diagnosis)
• Bupropion (therapeutic use)
• Child
• Dopamine Uptake Inhibitors (therapeutic use)
• Feasibility Studies
• Female
• Humans
• Male
• Pilot Projects
• Surveys and Questionnaires
• Tobacco Use Disorder (complications, diagnosis, drug therapy)