Fozivudine: BM 211290, fozivudine tidoxil, FZT, HDP 990002, W 09726867.

Abstract

Fozivudine [BM 211290, fozivudine tidoxil, FZT, HDP 990002, W 09726867] is a thioether lipid conjugate of zidovudine (AZT) in clinical development with Heidelberg Pharma Holdings for the potential treatment of HIV infection. Heidelberg Pharma's proprietary Linker-Cleavag-Enzyme Technology (LCE_Technology) is used to conjugate specific carriers to parent compounds, significantly improving their pharmacological, toxicological and/or clinical profile. LCE_Technology was originated at Boehringer Mannheim, which was acquired by, and integrated into, Roche. In 1999, when Heidelberg Pharma was founded, following a management buy-out from Roche Diagnostics GmbH, the new company acquired full ownership of the intellectual property and documentation related to various proprietary compounds, the LCE_Technology and its applications. According to Heidelberg Pharma's pipeline, published in August 2003, the product candidate, HDP 99.0002 (the company-specific code for fozivudine) will be in phase III development until early 2006, at which time the company hopes to file an NDA. A phase II study of fozivudine in 72 antiretroviral-naive patients with HIV infection was completed in the US and France by Roche.

• Journal: Drugs in R&D (Drugs R D) Vol. 5 Issue 1 Pg. 41-3 ( 2004) ISSN: 1174-5886 [Print] New Zealand
• PMID: 14725491 (Publication Type: Journal Article, Review)

Chemical References

• Anti-HIV Agents
• Drugs, Investigational
• Lipids
• Zidovudine
• fozivudine tidoxil

Topics

• Animals
• Anti-HIV Agents (pharmacokinetics, therapeutic use)
• Drugs, Investigational (pharmacokinetics, therapeutic use)
• HIV Infections (blood, drug therapy)
• Humans
• Lipids (pharmacokinetics, therapeutic use)
• Zidovudine (analogs & derivatives, pharmacokinetics, therapeutic use)