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[Chronic urticaria, thyroiditis and autologous serum test]

AbstractINTRODUCTION: The autoimmune nature of certain forms of chronic urticaria remains debatable. Aim of the study. To find a correlation in terms of autoimmune pattern between chronic urticaria and thyroiditis using the autologous serum test and the search for anti-thyroid antibodies. PATIENTS AND METHODS: Study in a single center of 59 patients having consulted for urticaria that had progressed for more than six weeks and without precise etiology. An autologous serum test was conducted and anti-thyroid autoantibodies were searched for in the serum stored after the test. RESULTS: Out of 59 patients, 51 had an interpretable autologous serum test and 57 underwent research for anti-thyroid antibodies. Twelve patients out 57 (21 p.cent) exhibited one or more types of positive (n=10) or borderline (n=2) anti-thyroid antibodies, and eight out of 12 (66.6 p.cent) had a known thyroid disease before the onset of urticaria. The systematic blood test permitted the discovery of 4 cases of unknown anti-thyroid antibodies. The symptoms regressed in two of these patients without any specific treatment, one patient was treated with L thyroxin for hyperthyroidism without any improvement in the symptoms and one other patient had normal thyroid function. Among these 12 patients, 11 underwent autologous serum tests, but only 3 of them exhibited clearly positive results and one was doubtful. CONCLUSIONS: Within the limits of this study, we found a 21 p.cent rate of patients with chronic urticaria exhibiting one or more anti-thyroid antibodies. The positivity of the autologous serum test does not appear to be related with autoimmune thyroid disorders.
AuthorsC Vermeulen, P Mathelier-Fusade, A-M Rouquette, O Bayrou, C Pecquet, F Leynadier (Affiliation: Centre d'Allergologie, Hôpital Tenon, Paris. christophe.vermeulen at hcuge.ch)
JournalAnnales de dermatologie et de vénéréologie (Ann Dermatol Venereol) Vol. 130 Issue 12 Pt 1 Pg. 1115-8 (Dec 2003) ISSN: 0151-9638 France
Vernacular TitleUrticaire chronique, thyroïdite auto-immune et test au sérum autologue.
PMID14724513 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Autoantibodies
Topics
  • Adolescent
  • Adult
  • Aged
  • Autoantibodies (blood)
  • Child
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Middle Aged
  • Thyroiditis, Autoimmune (blood, diagnosis)
  • Urticaria (blood, diagnosis)